مقایسه آنتی مولرین هورمون و سایر هورمون های جنسی در خانم های مبتلا به سندروم تخمدان پلی کیستیک و گروه شاهد

Background: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy of premenopausal women in different populations. There is no precise consensus on the exact definition of this disorder and there is no laboratory criterion so it is useful to find a laboratory marker for diagnosis. Anti mullerian hormone (AMH) produced by the granulosa cells of small follicles in the early stages of follicular growth, has recently been proposed as a marker for the diagnosis of PCOS. This study was performed to compare AMH levels in PCOS versus nonPCOS patients and determine its relation to other parameters especially hormone levels. Methods: This case-control study was carried out on 176 patients who attended Vali-e-Asr clinic. Eighty eight patients were diagnosed as the PCOS group according to the Rotterdam criteria and 88 normal ovulatory women participated as the control group. AMH and other data from both groups were recorded and analyzed using the SPSS software version 19. Results: Based on the results obtained in the two groups, it was shown that in women with PCOS, mean Anti-mullerian hormone (AMH) level is significantly higher (8.7 versus 2.9ng/ml) independent of other factors (p<0.0001). Conclusion: According to this study, Anti-mullerian hormone is significantly higher in PCOS patients when compared to normal ovulatory women without relation to other findings in this disorder. Hence it can probably be used as an independent marker for diagnosing PCOS. Nevertheless further studies are recommended to establish its value.